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Dr Lisa Mielke

Head, Mucosal Immunology Laboratory

More about Dr Lisa Mielke

I am inspired by the complex immune cell networks that exist in the intestine and I strive every day to unlock the potential of harnessing immune cells to enhance the killing of tumour cells.  

I am a Victorian Cancer Agency Fellow and Head of the Mucosal Immunity and Cancer Laboratory at the Olivia Newton-John Cancer Research Institute. I currently maintain honorary appointments at the Walter and Eliza Hall Institute, the University of Melbourne, and La Trobe University. I am an expert in immune cell biology in intestinal homeostasis and gastrointestinal cancers and obtained my PhD from the National Institutes of Health, USA, in 2009, before performing my postdoctoral studies at Trinity College in Dublin, Ireland, and the Walter & Eliza Hall Institute of Medical Research in Melbourne, Australia. I led numerous studies during this time that revealed correlations between our diet and the transcriptional regulation of intestinal innate lymphoid cell (ILC) and gd T cell populations. These studies opened up an exciting new frontier of research in the field of mucosal immunology, which underpins my current work studying the role of these cells in gastrointestinal cancers.

Education

PhD, Department of Medical Biology, The University of Melbourne, Australia & The National Institutes of Health, Maryland, USA (The Walter and Eliza Hall Institute of Medical Research (WEHI)), 2006-2009

Bachelor of Science (Honours), First class, Department of Medical Biology, The University of Melbourne & WEHI, 2001-2004

Current Appointments

Head, Mucosal Immunity and Cancer Laboratory, Olivia Newton-John Cancer Research Institute

Achievements

Mid Career Research Fellowship, Victorian Cancer Agency, 2019-2022 

Priority Driven Young Investigator Grant, Cure Cancer Australia, 2017-2018 

Superstar of STEM, Science and Technology Australia, 2017

Project grant, CIB, National Health and Medical Research Council, 2013-2015

Priority Driven Young Investigator Grant, CIA, Cure Cancer Australia, 2013 

Postdoctoral Investigator Award, International Cytokine and Interferon Society, 2011

Outstanding Scholar Award, International Cytokine Society, 2008 

Recent Publications

  1. O'Reilly LA**, Putoczki TL**, Mielke LA, Low JT, Lin A, Preaudet A, Herold MJ, Yaprianto K, Tai L, Kueh A, Pacini G, Ferrero RL, Gugasyan R, Hu Y, Christie M, Wilcox S, Grumont R, Griffin MDW, O'Connor L, Smyth GK, Ernst M, Waring P, Gerondakis S, Strasser A. 2018. Loss of NF-kB1 Causes Gastric Cancer with Aberrant Infalmmation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner. Immunity. 48:570-583. ** These authors contributed equally.
  2. Seillet C, Mielke LA, Amann-Zalcenstein DB, Su S, Gao J, Almeida FF, Shi W, Ritchie ME, Naik SH, Huntington ND, Carotta S, Belz GT. 2016. Deciphering the innate lymphoid cell transcriptional program. Cell Reports. 17:436-447.
  3. Dunne A**, L.A. Mielke**, A. Allen, C.E. Sutton, R. Higgs, S.C. Higgins and K.H.G. Mills. 2014. A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective cellular immunity with an acellular pertussis vaccine. Mucosal Immunology. 8:607-17 ** These authors contributed equally.
  4. Mielke, L. A., J. R. Groom, L. C. Rankin, C. Seillet, F. Masson, T. Putoczki, and G. T. Belz. 2013. TCF-1 controls ILC2 and NKp46+RORgammat+ innate lymphocyte differentiation and protection in intestinal inflammation. Journal of immunology 191: 4383-4391.
  5. Mielke, L. A., S. A. Jones, M. Raverdeau, R. Higgs, A. Stefanska, J. R. Groom, A. Misiak, L. S. Dungan, C. E. Sutton, G. Streubel, A. P. Bracken, and K. H. Mills. 2013. Retinoic acid expression associates with enhanced IL-22 production by gammadelta T cells and innate lymphoid cells and attenuation of intestinal inflammation. The Journal of experimental medicine 210: 1117-1124.

 

Ph: +61 3 9496 9126

E: lisa.mielke@onjcri.org.au

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