research-program-hero

Our research programs

Our researchers are investigating and developing treatments for a broad spectrum of cancer types.

Researchers at the Olivia Newton-John Cancer Wellness & Research Centre are committed to making scientific discoveries that benefit patients living with cancer. 

StuMorley-0522 laboratories2168 140904-jamesbraund-0918

Our research programs

At the Olivia Newton-John Cancer Research Institute we are uniquely positioned within a hospital, meaning we can focus on a broad spectrum of cancer types. Our laboratories are directly opposite patient wards, so our researchers can see the impact their research is making and accelerate learning between the bench and the bedside.

180315 ONJCRI PORTRAIT MARIAH 0004

CANCER AND INFLAMMATION LABORATORY

Amongst many other functions, inflammatory processes support the progression of tumours. We focus on understanding how cancers cells thrive by exploiting inflammatory processes, corrupting surrounding normal cells and avoiding immune detection.

Learn more
Inflammation-1400x700_5

TUMOUR MICROENVIRONMENT AND CANCER SIGNALLING LABORATORY

Learn more
170330 ONJCRI 0286 edit

CANCER THERAPEUTICS RESEARCH LABORATORY

By understanding how pro-inflammatory cytokines facilitate the growth and spread of cancer cells, we have been able to identify molecular targets, for which we are now developing targeted treatments.

Learn more
laboratories 0032

CANCER IMMUNOBIOLOGY LABORATORY

Through understanding the biology of cancer cells and their interaction with the immune system we are able to discover and trial novel therapies to induce the immune system to detect and fight cancer cells.

Learn more
laboratories2236 edit

TUMOUR IMMUNOLOGY LABORATORY

By analyzing patient samples from clinical trials and using a mixture of innovative technologies both emerging and established, we are gaining insights into the complex network of interactions between the immune system and tumour cells. This will help us to better predict, understand and ultimately induce immune-responses that will lead to long-term cancer control in patients.

Learn more
10alexteam

TRANSLATIONAL GENOMICS AND EPIGENOMICS LABORATORY

Every cancer patient responds to treatment differently because every person is unique. Our aim is to develop diagnostic tools that detect the effectiveness of treatment for an individual at any stage of their cancer journey. With the availability of precise and rapid information, clinicians and patients will be able to make better treatment decisions sooner.

Learn more
laboratories 0044 edit

ONCOGENIC TRANSCRIPTION LABORATORY

The health of the gastrointestinal system is reliant on a continual cycle of cell replacement. In cancers of the gastrointestinal system, this cycle is disrupted. We investigate the role of genes and proteins in the onset of cancer, with the goal of identifying new treatment targets for this disease.

Learn more
13dougfairlieteam

CELL DEATH AND SURVIVAL LABORATORY

We study the molecular pathways that control the fate of a cell which are often deregulated in cancer cells. By understanding the survival factors that keep cancer cells alive we aim to develop new and effective drugs that can activate natural cell death or inhibit impaired survival mechanisms in tumour cells.

Learn more
180315 ONJCRI MR 0054 edit

METASTASIS RESEARCH LABORATORY

Learn more
170330 ONJCRI 0641 edit

Matrix Microenvironment and Metastasis Laboratory

As part of the Translational Breast Cancer Program, we are interested in how and why some breast cancers preferentially spread to bone or brain. We have identified key matrix proteins that are laid down by cancer and surrounding normal cells and provide a substrate on which cancer cells attach, survive and spread to distant organs. Our research aims to develop new therapies that block the function or production of these matrix proteins and prevent cancer spread to bone and brain.

Learn more
180315 ONJCRI TPH 0216 edit

Tumour Progression and Heterogeneity Laboratory

We seek to ‘Track and Treat’ the cancer cells present in patients’ tissues by using lineage tracing, as well as sequencing technologies, to determine the molecular mechanisms responsible for the dissemination of cancer cells to various organs, and resistance to current therapies.

Learn more
laboratories2081

Tumour Targeting LABORATORY

We target tumours by exploring how the proteins found on the cancer cell surface can be utilised to inhibit growth or kill tumours. We develop antibodies that may help us detect cancer cells through highly sensitive medical imaging technologies, as well as antibodies that directly trigger cell-killing mechanisms in the tumour.

Learn more

Find out more about clinical trials

LEARN MORE