Love Your Sister and ONJCRI partnership focusses on the future of personalised medicine
Published 12 March 2019
Scanning barcodes to beat breast cancer
Published 12 March 2019
ACRF Award $2 Million To ONJCRI
Published 9 November 2018
Ian Potter Foundation - Support of the ONJCRI
Published 8 November 2018
Dr Andreas Behren, Head of the Tumour Immunology Laboratory
While we often hear in the media that the survival rate of women diagnosed with breast cancer is increasing, unfortunately the survival rate for women with secondary breast cancer – also known as metastatic breast cancer - paints a very different picture.
Love Your Sister and Olivia Newton-John Cancer Research Institute (ONJCRI) are now working together to try and change this statistic with the help of a dedicated Research Assistant who will work with ONJCRI researchers Dr Belinda Yeo and Dr Delphine Merino - two of Australia’s leading breast cancer research experts.ate of women diagnosed with breast cancer is increasing, unfortunately the survival rate for women with secondary breast cancer – also known as metastatic breast cancer - paints a very different picture.
Belinda is a medical oncologist who treats breast cancer patients. Delphine runs a breast cancer lab at ONJCRI that specifically deals with the cancer cells responsible for forming metastatic cancers. And while they make a great team, this new Research Assistant will bridge a gap to turn their ultimate goal of giving women with metastatic breast cancer alternative treatment options.
The initial 3 years study which will be conducted onsite at ONJCRI will see the Research Assistant obtain necessary consent from patients who are willing to donate their tumour sample to research, transport the precious samples to the laboratory and process it through the ONJCRI Tumour Progression and Heterogeneity Laboratory part of the ONJCRI Translational Breast Cancer Program led by renowned breast cancer researcher Professor Robin Anderson
Dr Delphine Merino and her team are using a technique commonly found in the aisles of supermarkets to conduct cutting-edge cancer research.
Their work follows on from a paper Delphine co-authored which was published in the prestigious journal Nature Communications.
Her team at the Institute is using barcodes to identify, track and analyse the genetic properties of aggressive breast cancer cells that spread to other parts of the body or resist drug treatment.
Delphine co-authored a paper in the journal Nature Communications, which she produced with Dr Salin Naik, Professor Jane Visvader and Professor Geoffrey Lindeman at the Walter and Eliza Hall Institute of Medical Research.
Their study shows that the barcoding technique can be used to track how breast cancer cells spread to different parts of the body.
The researchers found that only a few cells were responsible for the metastasis of a tumour and these cells were the ‘seeds’ causing new tumour growth.
The research is an important step in understanding how cancer cells spread from the breast to other organs.
The ACRF Centre for Imaging the Tumour Environment is a state of the art imaging centre to understand how and why tumours corrupt the normal cells of their immediate environment.
The Australian Cancer Research Foundation awarded the Olivia Newton John Cancer Research Institute $2million to establish this centre. The centre enables ONJCRI and La Trobe Institute of Molecular Science to extend its ground- breaking work and accelerate the transition of laboratory results into cancer treatments that will benefit all Australian Cancer patients.
“This new centre will allow us to look at the environment in which cancer cells and tumours grow, giving us the information we need to develop effective, targeted antic-cancer therapies”
Prof Matthias Ernst, Scientific Director of ONJCRI & Head of the School of Cancer Medicine Latrobe University
To find out more about the Australian Cancer Research Foundation, please visit www.acrf.com.au
In 2015 The Ian Potter Foundation awarded a grant of $450,000 to the Olivia Newton-John Cancer Research Institute to partially fund the purchase of a Vectra System.
This equipment allows researchers to visualise multiple cell types in a single tumour and therefore characterise normal and abnormal cells within a samples. It has allowed us to comprehensively analyse a patient's cancer and immune make-up to identify biomarkers of treatment response. This informs the selection of patients for clinical trials with immune therapeutics. This equipment has quickly become a highly sought after resource by our research teams and collaborators, which prompted a submission to the Ian Potter Foundation in support of the automation equipment to improve the sample processing time and allow a higher throughout put of use by researchers.
The purchase of the Vectra system in 2015 was also supported with funding from ONJCRI, La Trobe University, the Peter MacCallum Cancer Centre and Austin Health.
In September 2018 the ONJCRI, with co-funding support from La Trobe University, and support of the Victorian Comprehensive Cancer Centre - VCCC and the Peter MacCallum Cancer Centre, was awarded a further grant to support the purchase of the automation equipment.
Along with these supporting research institutes, the equipment will support all member institutes of the Victorian VCCC including the PDI, Austin health and Walter and Eliza Hall Institute. The addition of this vital equipment to the ONJCRI is an illustration of the collaborative work of researchers from Melbourne cancer research teams.
The grants, each lead by Dr Andreas Behren, Head of the Tumour Immunology Laboratory, together provide a platform of technology that is at the forefront of cancer patient sample analysis. As a member of the VCCC, this equipment will enhance the VCCCs capacity to perform world‐class medical research and further strengthen and enhance cross‐institutional collaboration including academic‐industry and hospital‐academic cross‐collaborations.
The ONJCRI welcomes researchers wishing to use the equipment in their research. To find out more please contact Dr Andreas Behren: firstname.lastname@example.org