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Dr Dinesh Raghu

Postdoctoral research fellow

More about Dr Dinesh Raghu

My passion for science began at an early age during my high school studies. I have since then been inspired to dedicate my career to answering critical medical research questions and translating those solutions from a research setting to the clinic.

Having spent the last three-and-a-half years as a PhD student at the Peter MacCallum Cancer Centre, Melbourne, I joined the ONJCRI in 2018 to pursue my research career in cancer immunology. I am currently placed in the Mucosal Immunity and Cancer lab, which is headed by Dr Lisa Mielke. We study how innate immune cells contribute to immunity, inflammatory bowel disease and bowel cancer. We use patient samples, pre-clinical models, and high throughput techniques such as flow cytometry, global- and single-cell RNA sequencing, and multiplex immunofluorescence.

Our ultimate objectives are to target immune cells in inflammatory bowel disease and bowel cancer, to develop better treatments for these diseases, and to establish a platform that can identify patients who will achieve a better clinical outcome from treatments targeting their immune cells to either reduce intestinal damage in inflammatory bowel disease or enhance tumour cell killing in the context of cancer.

I am also actively involved in contributing to school programs by presenting my research work to young inquisitive minds and inspiring them to pursue careers in health science and technology.

Education

2018 Doctor of Philosophy, The University of Melbourne, Australia

2014 Master of Science by Research, Indian Institute of Technology, India

2011 Bachelor of Technology, Anna University, India

Current Appointments

Postdoctoral Research Fellow, Olivia Newton-John Cancer Research Institute, Melbourne

Honorary Associate, School of Cancer Medicine, La Trobe University

Achievements

2014 - 2018 Melbourne International Fee Remission scholarship (MIFRS), The University of Melbourne

2014 - 2018 Melbourne International Research scholarship (MIRS), The University of Melbourne

2012 – 2014 Ministry of Human Resource and Development Fellowship, Indian Institute of Technology, Madras

2011 Best All Rounder Student award in Undergraduate

2010 Summer Research Fellowship, Indian Academy of Sciences

Recent Publications

Gulati, T., Huang, C., Caramia, F., Raghu, D., Paul, J.P., Goode, R. J.A., Keam, S.P., Williams, S.G., Haupt, S., Kleifeld, O., Schittenhelm, R.B., Gamell, C., Haupt, Y. (2018) Proteomtranscriptomic measurements of E6-Associated Protein (E6AP) targets in DU145 prostate cancer cells. Molecular & Cellular Proteomics.
Raghu, D., Paul, J.P., Gulati, T., Deb, S., Khoo, C., Russo, A., Gallo, E., Blandino, G., Chan, A., Takano, E.A., Fox, S.B., Williams, S., Haupt, S., Gamell, C., Haupt, Y. (2017) E6AP promotes prostate cancer by reducing p27 expression. Oncotarget 8: 42939-48.
Miranda, PJ., Buckley, D., Raghu, D., Pang, J.B., Takano, E.A., Vijayakumaran, R., Teunisse, A., Posner, A., Procter, T., Herold, M.J., Gamell, C., Marine, J.C., Fox, S.B., Jochemsen, A., Haupt, S., Haupt, Y. (2017) MDM4 is a rational target for treating breast cancer with mutant p53. Journal of Pathology 241: 661-70.
Raghu, D*., Piotr, J.P*., Chan, A., Gulati, T., Herold, M.J., Hagekyriakou, J., Vessella, R.l., Fedele, C., Shackleton, M., Williams, E.D., Fox, S.B., Williams, S., Haupt, S., Gamell, C., Haupt, Y. (2016) Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP.Oncogene. 35: 6235-645. (*Equal contribution)
Raghu, D and Karunagaran, D. (2014) Plumbagin downregulates WNT signaling independent of p53 in human colorectal cancer cells. Journal of Natural Products. 77: 1130−34.